| Knotty Brewing Co | 842 Market St | San Diego | California | 92101-6425 | United States | micro | |
| Latchkey Brewing Co | 1795 Hancock St Mission Brewery Plaza | San Diego | California | 92110-2006 | United States | micro | |
| Little Miss Brewing | 7949 Stromesa Ct Ste Y | San Diego | California | 92126-6338 | United States | micro | |
| Longship Brewery | 10320 Camino Santa Fe Ste C | San Diego | California | 92121-3103 | United States | closed | |
| Mike Hess Brewing | 3812 Grim Ave | San Diego | California | 92104-3602 | United States | micro | |
| Mike Hess Brewing - Miramar | 7955 Silverton Ave Ste 1201 | San Diego | California | 92126-6357 | United States | micro | |
| Mikkeller Brewing San Diego | 9366 Cabot Dr | San Diego | California | 92126-4311 | United States | micro | |
| Mission Brewery | 1441 L St | San Diego | California | 92101-8967 | United States | micro | |
| Modern Times - The Dankness Dojo | 3725 Greenwood St | San Diego | California | 92110-4441 | United States | brewpub | |
| Modern Times Barrel House | 3486 Kurtz St # 102 | San Diego | California | 92110-4429 | United States | micro | |
| Modern Times Beer | 3725 Greenwood St | San Diego | California | 92110-4441 | United States | regional | |
| Monkey Paw Brewing | 807 16th St | San Diego | California | 92101-6610 | United States | micro | |
| New English Brewing Co Inc | 11545 Sorrento Valley Rd Ste 305 | San Diego | California | 92121-1322 | United States | micro | |
| North Park Beer Co. | 3038 University Ave | San Diego | California | 92104-3002 | United States | micro | |
| Ocean Beach Brewery | 5041 Newport Ave | San Diego | California | 92107-3009 | United States | brewpub | |
| Oggis Pizza & Brewing Co - Carmel Mountain Ranch | 10155 Rancho Carmel Dr | San Diego | California | 92128-3609 | United States | brewpub | |
| Oggis Pizza & Brewing Co - Mission Valley | 2245 Fenton Pkwy Ste 108 Fenton Marketplace | San Diego | California | 92108-4737 | United States | brewpub | |
| Pacific Beach Ale House | 721 Grand Ave | San Diego | California | 92109-3905 | United States | brewpub | |
| Pariah Brewing Company | 3052 El Cajon Blvd Ste B | San Diego | California | 92104-1618 | United States | micro | |
| Pizza Port Ocean Beach | 1956 Bacon St | San Diego | California | 92107-2844 | United States | brewpub | |
| Poor House Brewing | 4494 30th St | San Diego | California | 92116-4287 | United States | micro | |
| Protector Brewery | 8680 Miralani Dr Ste 128 | San Diego | California | 92126-6392 | United States | micro | |
| Pure Project | 9030 Kenamar Dr Ste 308 | San Diego | California | 92121-2432 | United States | micro | |
| Quantum Brewing Co | 5375 Kearny Villa Rd Ste 116 | San Diego | California | 92123-1422 | United States | micro | |
| Resident Brewing | 411 C St | San Diego | California | 92101-5105 | United States | micro | |
| Rip Current Brewing North Park | 4101 30th St | San Diego | California | 92104-1905 | United States | brewpub | |
| Rough Draft Brewing | 8830 Rehco Rd Ste D | San Diego | California | 92121-3263 | United States | micro | |
| Saint Archer Brewing Company | 9550 Distribution Ave | San Diego | California | 92121-2306 | United States | large | |
| San Diego Brewing Co | 10450 Friars Rd Ste L | San Diego | California | 92120-2311 | United States | brewpub | |
| Savagewood Brewing Company | 9879 Hibert St Ste F | San Diego | California | 92131-1058 | United States | micro | |
| Second Chance Beer Company | 15378 Ave of Science Ste 222 | San Diego | California | 92128-3451 | United States | micro | |
| Societe Brewing Company | Societe Brewing Company 8262 Clairemont Mesa Blvd | San Diego | California | 92111-1702 | United States | micro | |
| South Park Brewing | 1517 30th St | San Diego | California | 92102-1503 | United States | brewpub | |
| Stone Brewing World Bistro & Gardens- Liberty Station | 2816 Historic Decatur Rd Ste 116 | San Diego | California | 92106-6164 | United States | brewpub | |
| Stover Brewing | | San Diego | California | 92124-1426 | United States | planning | |
| Tenacious Brewing Company | | San Diego | California | 92101 | United States | planning | |
| The Bell Marker | 602 Broadway Ste 101 | San Diego | California | 92101-5449 | United States | brewpub | |
| Thorn Brewing Co | 1745 National Ave. | San Diego | California | 92113-1010 | United States | micro | |
| Thorn Street Brewery | 3174 Thorn St | San Diego | California | 92104-4636 | United States | micro | |
| Thunderhawk Alements | 8675 Miralani Dr Ste 100 | San Diego | California | 92126-4355 | United States | micro | |
| White Labs Tasting Room | 9495 Candida St | San Diego | California | 92126-4541 | United States | micro | |